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preprint · 2025

Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction

Saro Passaro, Gabriele Corso, Jeremy Wohlwend, Mateo Reveiz, Stephan Thaler, Vignesh Ram Somnath, Noah Getz, Tally Portnoi

Accurately modeling biomolecular interactions is a central challenge in modern biology. While recent advances, such as AlphaFold3 and Boltz-1, have substanti...

286 citationsDOI: https://doi.org/10.1101/2025.06.14.659707Open access