Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer

Armina A. Kazi, Rabia A. Gilani, Amanda Schech, Saranya Chumsri, Gauri Sabnis, Preeti Shah, Olga Goloubeva, Shari S. Kronsberg

One of the mechanisms of AI resistance may be through regulation of nonhypoxic HIF-1 target genes, such as BCRP, implicated in chemoresistance. Thus, HIF-1 s...