Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig

Antoine Roch, Christian Woloch, Dorothée Blayac, Caroline Solas, Sylvie Quaranta, Vincent Mardelle, Matthias Castanier, Laurent Papazian

Hypovolaemic shock followed by fluid loading in the pig results in a significant increase in the apparent volume of distribution of caspofungin and in a decr...