Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5- d ]azepines as Potent 5-Hydroxytryptamine 2C (5-HT 2C ) Receptor Agonists with Exquisite Functional Selectivity over 5-HT 2A and 5-HT 2B Receptors

A series of 4-substituted pyrimido[4,5-d]azepines that are potent, selective 5-HT2C receptor partial agonists is described. A rational medicinal chemistry de...