Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance–associated protein 1 and provokes high levels of cross‐resistance to glucocorticoids

Ruud Oerlemans, Joost van der Heijden, Josefien Vink, Ben A. C. Dijkmans, Gertjan J.L. Kaspers, Willem F. Lems, George L. Scheffer, Ilan Ifergan

Induction of overexpression of the multidrug resistance efflux transporter MRP-1 can emerge after long-term exposure to CQ and results in CQ resistance and c...