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article · 2013

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

The tetrasaccharide heparan sulfate (HS) mimetic PG545, a clinical anti-cancer candidate, is an inhibitor of the HS-degrading enzyme heparanase. The kinetics...

59 citationsDOI: https://doi.org/10.1016/j.fob.2013.07.007Open accessPDF reported by metadataFull text reported by metadata
Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues