Deviation from additivity in mixture toxicity: relevance of nonlinear dose-response relationships and cell line differences in genotoxicity assays with combinations of chemical mutagens and gamma-radiation.

Werner K. Lutz, Spyros Vamvakas, Annette Kopp‐Schneider, J. Schlatter, Helga Stopper

Sublinear dose-response relationships are often seen in toxicity testing, particularly with bioassays for carcinogenicity. This is the result of a superimpos...