Preexisting Neutralizing Antibodies to Adeno-Associated Virus Capsids in Large Animals Other Than Monkeys May Confound In Vivo Gene Therapy Studies

Roberto Calcedo, Judith Franco, Qiuyue Qin, Dean W. Richardson, Jeffrey B. Mason, Surina Boyd, James M. Wilson

Adeno-associated virus (AAV) vectors are currently being tested not only in small animal models such as mice but also in large animal models, including pigs,...